VPH 2012 – Conference proceeding
Publication
Yves Martelli, Tristan Whitmarsh, Ludovic Humbert, François Chung, Luis M. del Río Barquero, Silvana Di Gregorio, Luigi Carotenuto, Alejandro F. Frangi; A software framework for 3D reconstruction and fracture risk assessment of the proximal femur from dual-energy x-ray absorptiometry; VPH 2012: Virtual Physiological Human - Integrative approaches to computational biomedicine, London, 2012.
Abstract
In clinical routine, osteoporosis diagnosis is performed using the areal Bone Mineral Density (aBMD) computed from two-dimensional Dual-energy X-ray Absorptiometry (DXA) images. This measurement of the "projected density" gives a global marker of osteoporosis but is insufficient for an accurate quantification of non-uniform mineral deficiencies. Quantitative Computed Tomography (QCT) is one possible modality for retrieving shape and bone mineral density measurements in 3D, leading to a better characterization of the local bone quality and the fracture risk. However, due to high financial costs and a high radiation dose for the patient, this modality is rarely used in clinical routine for the follow-up of osteoporosis. In this work, we show how state-of-the-art techniques and methods for fracture risk assessment of the proximal femur using 3D analysis from single-view DXA images were brought to the research and clinical end-user, through the use of an existing open source framework for fast prototyping of clinical applications.
References
Publication
Preprint version (PDF)
Bibliographic reference (BibTeX)
Related article
GIMIAS framework (UPF project)
Learn more
VPH – Virtual Physiological Human
